NCT07598617 · RECRUITING
The Co-Production and Evaluation of the Computerised Cognitive Assessment for Preclinical Alzheimer's Disease (CoCoA-PAD)
This UK study is developing and testing a new computerized memory assessment designed to catch Alzheimer's disease at its earliest stages. The goal is to see whether memory nurses — rather than specialist doctors — can reliably administer this test, easing pressure on the NHS. It is not a drug trial. Participants complete a cognitive test, a brain scan, and a blood test. The phase is unspecified, meaning this is early-stage development and validation work, not a treatment study.
Eligibility criteria
Recruitment Criteria for Subjective Cognitive Decline and Mild Cognitive Impairment Subjective Cognitive Decline Inclusion Criteria * >3.38 on IQCODE Self-Report items 1-7 (PROTECT) OR * ≥4 on SCD-Q9 (non-Protect) AND * Age ≥65 years * Onset of SCD within the last 5 years * English as a first language * Normal demographically adjusted performance on standardised cognitive tests * Specific Race and Education (using stratified sampling approach) Exclusion Criteria * Cognitive impairment, i.e., performance ≥1 SD below demographically adjusted norms (PROTECT) OR * ≤17 on the telephone MoCA (non-PROTECT) AND * Lacks mental capacity to consent to research * Diagnosis of dementia * Sensory impairment that cannot be corrected for with sensory aids, e.g., blindness. * Previous neurological injury (stroke, traumatic brain injury, severe epilepsy, brain tumour) * Other neurodegenerative syndrome (e.g., Parkinson's disease, multiple sclerosis, etc) * Diagnosis of learning disability * Severe depression (PHQ-9≥15 OR score ≥1 on PHQ-9 suicide question * Current severe psychiatric disorder (bipolar disorder, schizophrenia, or psychotic disorders) * Current drug or alcohol abuse * Untreated diagnosis of sleep apnoea. Mild Cognitive Impairment Inclusion Criteria * >3.38 on IQCODE Self-Report items 1-7 (PROTECT) * Cognitive impairment, i.e., performance ≥1 SD below demographically adjusted norms (PROTECT) OR * ≥4 on SCD-Q9 (non-PROTECT) * ≤17 on the telephone MoCA (non-PROTECT) OR * MCI diagnosis according to DSM or ICD-11 criteria through an NHS memory clinic. AND * Age ≥65 years * Onset of SCD within the last 5 years * English as a first language * Specific Race and Education (using stratified sampling approach) Exclusion Criteria * A score of ≥3 on any item on the Instrumental Activities of Daily Living scale, subject to clinical judgement. * Lacks mental capacity to consent to research * Diagnosis of dementia * Sensory impairment that cannot be corrected for with sensory aids, e.g., blindness. * Previous neurological injury (stroke, traumatic brain injury, severe epilepsy, brain tumour) * Other neurodegenerative syndrome (e.g., Parkinson's disease, multiple sclerosis, etc) * Diagnosis of learning disability * Severe depression (PHQ-9≥15 OR score ≥1 on PHQ-9 suicide question * Current severe psychiatric disorder (bipolar disorder, schizophrenia, or psychotic disorders) * Current drug or alcohol abuse * Untreated diagnosis of sleep apnoea.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-05-20