NCT07514520 · ACTIVE NOT RECRUITING
Decision-making, Ethical Consent, and Interactive Dialogue in Ongoing Neurocognitive Decline - DECISION
This study is building and testing a new, simpler tool to assess whether people with Alzheimer's or related dementias can meaningfully consent to medical decisions. It is not testing a drug or treatment. Researchers will also look at brain scans and blood biomarkers to understand how consent capacity relates to cognitive decline. This phase is unspecified, and no intervention is being given — it is an observational and tool-development study.
You may qualify if
- Age ≥ 50 years
- Diagnosis or suspected diagnosis of a neurocognitive disorder (e.g., Alzheimer's disease, frontotemporal dementia, vascular dementia, mixed forms) based on ICD-10 criteria
- Ability to provide informed consent, or availability of a legally authorized representative
- Sufficient language proficiency to complete cognitive assessments
- Availability of a trusted informant (e.g., caregiver or relative) for external rating instruments
- Willingness to participate in neuropsychological testing, blood sampling, and optional imaging
You're excluded if
- Severe sensory impairments (e.g., blindness, deafness) that prevent completion of assessments
- Acute psychiatric conditions (e.g., psychosis, severe depression) that interfere with study procedures
- History of major neurological disorders unrelated to dementia (e.g., traumatic brain injury, stroke with severe residual deficits)
- Uncontrolled systemic illness or unstable medical condition
- Refusal or inability to undergo necessary procedures (e.g., blood draw, optic coherence tomography, MRI)
- Participation in another interventional study that could interfere with the outcomes of this study
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-04-07