NCT07503743 · ACTIVE NOT RECRUITING
Biology-Driven Cognitive Profiling in Huntington's Disease
This trial is studying Huntington's disease, not Alzheimer's. Researchers are using a specialized PET brain scan with a tau-detecting tracer, MRI, and cognitive tests to build better tools for spotting early brain changes in HD gene carriers before symptoms appear. It is a small pilot study — early-stage research focused on measurement and biology, not testing a treatment. Details on long-term outcomes are limited at this stage.
Eligibility criteria
Inclusion Criteria: * Age between 18 and 75 years * Ability to provide written informed consent approved by the Ethics Committee * Ability to comply with study procedures, including PET imaging, MRI, cognitive testing, and blood sampling * Participants in the Healthy Control cohort must meet the following criteria: 1. No history of neurological or psychiatric disorders 2. No family history of Huntington's disease 3. Normal cognitive status based on clinical evaluation * Participants in the Premanifest Huntington's disease gene carrier cohort must meet the following criteria: 1. Genetically confirmed HTT CAG expansion (CAG > 38) 2. CAP score > 250 3. Unified Huntington's Disease Rating Scale - Total Motor Score (UHDRS-TMS) \< 4 4. Total Functional Capacity (TFC) = 13 5. Absence of manifest motor diagnosis (Diagnostic Confidence Level \< 4) * Participants in the Manifest Huntington's disease cohort (early-intermediate stage) must meet the following criteria: 1. Genetically confirmed HTT CAG expansion (CAG > 38) 2. Diagnostic Confidence Level (DCL = 4) confirming manifest Huntington's disease 3. CAP score > 350 4. Total Functional Capacity (TFC) > 6 Exclusion Criteria: * Any severe medical condition or circumstance that, in the investigator's judgment, may compromise safe participation in the study * Current or previous participation in the RG6042 / tominersen (mHTT-lowering) clinical trial * Participation in any interventional clinical trial within the last 12 months * Pregnancy or breastfeeding, or intention to become pregnant during the study period * Contraindications to PET imaging, MRI, or venous blood sampling
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-03-31