NCT07425769 · RECRUITING
Adapting RDAD for DS
This trial is testing a remote exercise and caregiver education program adapted for older adults with Down syndrome, who face a very high lifetime risk of Alzheimer's disease. Researchers want to see whether the program is practical to deliver and shows early signs of benefit. It is a feasibility study — a Phase N/A design meant to assess whether a larger, more definitive trial is worth running.
Eligibility criteria
Inclusion Criteria - Adults with Down syndrome: * Age >35 yrs. with a diagnosis of DS as self-reported or reported by caregiver. This age range was selected as cognitive decline related to AD is observed at age ~31 in adults with DS. * Sufficient functional ability to understand directions, communicate preferences, wants, and needs through spoken language. * Living at home or in a supported living environment with a parent/caregiver who agrees to serve as a study partner. * Self-reported ability to participate in physical activity. Exclusion Criteria - Adults with Down syndrome: * Unable to participate in moderate-to-vigorous physical activity. * Self-reported, cardiovascular, metabolic or renal disease and/or signs or symptoms. Inclusion Criteria - Caregivers * Age ≥18 yrs. * Reports being a primary caregiver of an adult with DS. * English speaking. * Self-reported ability to participate in physical activity. Exclusion Criteria - Caregivers * Unable to participate in moderate PA, i.e., brisk walking. * Self-reported, cardiovascular, metabolic or renal disease and/or signs or symptoms.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-05-06