NCT07361887 · RECRUITING
Deciphering the Effect of Moderate Wine Consumption on Healthy Aging Through Postprandial Extracellular Vesicles.
This trial gives healthy adults a single serving of red wine, white wine, or water, then draws blood before and after to study tiny cell-released particles called extracellular vesicles. Researchers want to see whether wine changes how those particles affect blood vessels, immune cells, and brain cells. This is a Phase N/A trial, meaning it is exploratory lab-level science, not a test of a treatment.
You may qualify if
- Healthy adult men and women aged 35 to 65 years.
- Body Mass Index (BMI) between 18.5 and 29.9 kg/m².
- Non-smokers or ex-smokers for at least 12 months.
- Moderate alcohol consumers, defined as ≤2 units/day for men and ≤1 unit/day for women.
- Normal fasting glucose and lipid profile at screening.
- Willing and able to refrain from alcohol, polyphenol-rich foods, and intense exercise for 48 hours before each study visit.
- Able to understand the study procedures and provide written informed consent.
You're excluded if
- History or clinical evidence of cardiovascular, hepatic, renal, thyroid, gastrointestinal, or metabolic diseases (including diabetes, dyslipidemia, or hypertension).
- Use of medications or supplements known to affect glucose, lipid, or inflammatory metabolism (e.g., statins, corticosteroids, anti-inflammatory drugs).
- Pregnancy or breastfeeding.
- Recent blood donation (within the last 3 months) or planned blood donation during the study period.
- Major weight change (>5% of body weight) within the last 3 months.
- Participation in another clinical or biomedical study within the previous 3 months.
- Known allergy or intolerance to wine, alcohol, or its components (e.g., sulfites).
- History of alcohol abuse or inability to abstain from alcohol outside the study context.
- Reluctance to receive information about incidental health findings arising from the study.
- Any condition judged by the investigators to limit compliance or increase study risk (e.g., psychiatric disorders, inability to adhere to fasting requirements).
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-01-23