NCT07348406 · Phase 1 · NOT YET RECRUITING
Snacks and Brain Health
This trial is testing whether eating a daily pecan snack improves memory, mood, and brain function in people over 50 who already have some cognitive impairment — compared to eating pretzels as a control snack. Researchers will also track changes in gut bacteria, inflammation markers, and gut-brain signaling over three months. This is a Phase 1 trial, meaning it is an early-stage study focused on safety and initial signals, not a proven treatment.
You may qualify if
- men and women > 50 years-old
- self-reported IQCODE (informant questionnaire on cognitive decline in the elderly) average score \< 4.5
- self-reported significant functional impairment (related to cognitive impairment) in basic or advanced activities of daily living as evidenced by the Activities of Daily Living (ADLs) questionnaire. If answers to at least one endorsement in the "NO, dependence due to memory concerns".
- Stable medications (≥ 12-week unchanged dose before baseline) with no planned changes during trial.
- habitually consume less than two servings (2 ozs = 1/4 cup) of nuts or nut spreads per week
- willing to accept randomization
You're excluded if
- reported nut allergy or intolerance
- self-reported untreated hypothyroidism, severe liver disease, or end-stage chronic kidney disease
- heavy alcohol drinker: in the past 3 months: men ≥14 drinks/week or women ≥7 drinks/week
- recent (\<1 month) appearance of diarrhea or hematochezia before study intervention begins. Rationale: A one-month waiting period after diarrhea or hematochezia (blood in stool) is recommended for a gut microbiome test to ensure the results accurately reflect the state and microbial composition, since diarrhea and hematochezia can significantly alter the gut environment and skew test results.
- recent (\<1 month) exposure to antibiotics before study intervention begins. Rationale: A one-month waiting period after antibiotics is recommended for a gut microbiome test because it allows the microbial community time to recover and reach a more stable state, ensuring a more accurate and representative snapshot of the gut microbiome composition, since antibiotic usage can significantly reduce microbial diversity.
- Self-reported unstable GI disorder
- likeliness of moving during the trial, lack of transportation, or unavailability at sample collection times
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-04-01