NCT07346794 · NOT YET RECRUITING
The Underlying Neural Mechanism of TMS in Improving the Imbalance of "Microbiota-brain-gut Axis" in Alzheimer 's Disease Population
This trial is testing whether repetitive transcranial magnetic stimulation (rTMS) — a non-invasive device that delivers magnetic pulses to the brain — can improve cognition in people with mild to moderate Alzheimer's by influencing the gut-brain connection. Researchers will track cognitive scores, gut bacteria, brain scans, and blood markers over one year. Phase NA means this is a mechanistic study aimed at understanding how rTMS works, not a late-stage efficacy trial.
You may qualify if
- Dementia Patients: Conformed to internationally recognized diagnostic criteria for dementia (e.g., DSM-5, NINCDS-ADRDA)
- Diagnosed through clinical evaluation, neuropsychological scale assessments, and relevant examinations
- Aged ≥50 years and residing in Nanchang, Jiangxi
- With dementia-negative family history, no severe psychiatric or neurological disorders
- No history of major systemic diseases.
You're excluded if
- Unable to cooperate with all required examinations, intervention procedures, and sample collection during the study.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-04-09