NCT07328386 · RECRUITING
Effect of Cervical Lymphaticovenous and Lymph Node-to-Vein Anastomosis in Patients With Intracranial Lymphatic Circulation Disorder
This trial is testing a surgical procedure called lymphaticovenous anastomosis — tiny connections made between lymphatic vessels and veins in the neck — to see whether it improves brain waste clearance and cognitive function in people with Alzheimer's disease. It is a Phase NA study, meaning this is early exploratory work assessing whether the procedure is feasible and shows any effect, not yet proven or approved.
You may qualify if
- Patients aged 19 years or older who are diagnosed with intracranial lymphatic circulation disorder based on neurological evaluation.
- Global Deterioration Scale (GDS) score between 3 and 5 at screening.
- Diagnosis of Alzheimer's disease confirmed by amyloid PET-CT or CSF amyloid testing, showing amyloid accumulation associated with lymphatic circulation disorder.
- Able to provide written informed consent to participate in the study voluntarily.
You're excluded if
- Unable to undergo follow-up evaluation for at least 12 months after surgery.
- Diagnosed with vascular dementia.
- Presence of structural brain disease other than intracranial lymphatic circulation disorder.
- Known hypersensitivity to indocyanine green (ICG).
- Uncontrolled systemic medical conditions such as severe cardiopulmonary, renal, hepatic, or endocrine disorders.
- History of previous neck surgery.
- Refusal to participate or failure to provide informed consent.
- Determined by the principal investigator to be unsuitable for participation due to any other clinical reason.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-01-09