NCT07201610 · NOT YET RECRUITING
Non-invasive Diagnosis of Parkinson's Disease
This study is testing whether non-invasive tools — eye imaging, cognitive tests, and voice analysis — can reliably detect Parkinson's disease without spinal taps or other invasive procedures. Researchers are comparing people already diagnosed with Parkinson's to healthy volunteers aged 60-80. There is no assigned treatment. The phase is unspecified, so think of it as early diagnostic research rather than a drug or therapy trial.
Eligibility criteria
Inclusion criteria for Parkinson's group: * Age 60-80 years * Diagnosis of idiopathic Parkinson's disease * Ability to understand spoken and written Swedish * Ability to personally provide consent to participate in the study * At least one healthy eye for retinal photography Inclusion criteria for control group: * Age 60-80 years * Ability to understand spoken and written Swedish * Ability to personally provide consent to participate in the study * At least one healthy eye for retinal photography * Healthy as defined below Exclusion criteria: * At least one eye must not have retinal disease, glaucoma, or vascular eye disease (such as embolism) * Angle-closure glaucoma or other contraindication to mydriatic drops * Low functional ability that makes participation in examinations impossible * Diagnosed dementia * Specifically for the control group: Not healthy according to the definition below Definition of healthy: * No diagnosed or suspected Parkinson's disease * No diagnosed or suspected cognitive disease * No psychiatric disease affecting cognition (e.g., psychotic disorder or major depression) * Cognitive testing with MMSE ≥ 26 points (out of a maximum of 30) and ≥ 8 points on the clock-drawing test
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-10-01