NCT07087951 · NOT YET RECRUITING
Efficacy of Gamma Auditory Stimulation for Cognitive Decline in Older Adults (Study 1)
This trial is testing whether listening to sound pulses at 40 Hz (a specific brainwave frequency) can improve memory and thinking in older adults who already have mild cognitive impairment or mild dementia. Researchers will compare an active sound device to a sham version to see if the stimulation affects cognition, brainwave patterns, sleep, and quality of life. This is a Phase NA trial, meaning it is evaluating effectiveness of a device rather than following a traditional drug-trial phase structure.
You may qualify if
- Age over 60 years old.
- MMSE≤ 24
- CDR scores of 0.5 and 1
- Voluntary to sign the Informed Consent Form.
You're excluded if
- Diagnosis of other psychiatric or neurological disorders
- Drug or alcohol addictions.
- Serious heart, liver or kidney disorders, and visual, auditory or motor impairments interfering with neuropsychological tests.
- History of clinical stroke, major depressive disorder or dysthymic disorder according to the DSM-5.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-08-14