NCT07060391 · Phase 3 · NOT YET RECRUITING
A Prospective Multicenter RCT Study of Deep Jugular Lymphovenous Anastomosis in the Treatment of Alzheimer's Disease
This trial is testing whether a surgical procedure called deep cervical lymphatic-venous anastomosis, which creates a new drainage connection in the neck to help clear waste from the brain, works better than the standard drug donepezil for people with moderate to severe Alzheimer's disease. It is a Phase 3 trial, meaning researchers are directly comparing the surgery against an existing treatment in a larger group to measure real-world effectiveness and safety over 48 weeks.
You may qualify if
- The patient was clinically diagnosed with Alzheimer's disease and had a moderate to severe cognitive function score.
- Age: 30-80 years old.
- Gender is not limited.
- The patient or their family members authorize their willingness to participate in this clinical trial and sign the informed consent form.
- no contraindications for surgery.
You're excluded if
- A history of radiotherapy or surgery for the head and neck.
- Patients or their families with poor compliance who cannot strictly follow the rules.
- Patients who cannot tolerate surgery.
- Patients with other diseases that affect cognitive function.
- Patients who cannot tolerate donepezil drug treatment.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-07-11