NCT07058129 · NOT YET RECRUITING
Deep Cervical Lymphatic Venous Anastomosis in the Treatment of Alzheimer's Disease (CLEAN-AD Registry)
This registry is tracking real-world outcomes for Alzheimer's patients who have already undergone a surgical procedure called deep cervical lymphatic venous anastomosis, or DC-LVA. The surgery connects lymphatic vessels in the neck to nearby veins, with the idea of improving the brain's drainage of waste. Researchers are measuring whether patients' dementia rating scores improve 12 months after surgery. This is a registry, not a randomized trial, so it is collecting observational data rather than testing the procedure in a controlled way.
You may qualify if
- Age ≥ 18 years, male or famale.
- Diagnosed with AD according to the NIA-AA criteria.
- Patients who have received DC-LVA treatment;
- Signed informed consent (by the subject or their relative, and caregiver)
You're excluded if
- Severe neurological deficits in limb movement, language, vision, hearing, or consciousness, or any condition that the investigator determines may prevent the completion of cognitive function assessments.
- The subject lacks a stable and reliable caregiver to accompany with them during entire study follow-up visits.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-07-10