NCT07007208 · Phase 2 · NOT YET RECRUITING
Biomarkers of the Locus Coeruleus Nucleus: Links With Early Tau Pathology, Cognition and Alzheimer's Disease Risk
This trial is studying a brain region called the locus coeruleus, which may show early signs of tau protein buildup before other areas affected in Alzheimer's. Researchers will use PET scans, MRI, eye-tracking, and cognitive tests to see whether changes in this region predict Alzheimer's risk and memory problems. It is a Phase 2 observational study — researchers are measuring and learning, not testing a treatment.
You may qualify if
- Participant in the INSPIRE-T cohort
- Normal cognitive assessment
- MMSE score ≥ 27 out of 30 (Mini-Mental State Examination)
- Normal visual abilities (in corrected or uncorrected vision)
- Normal motor skills
You're excluded if
- Subjects with a contraindication to MRI exam
- Subjects with a known allergic reaction to the PET radiopharmaceutical ([18F] Flortaucipir) or any of its excipients
- Subjects with an ophthalmological pathology making oculometric measurements difficult
- Subjects with neurological or psychiatric pathologies
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-12-16