NCT06965686 · RECRUITING
Development of a Personalized, Psychosocial Intervention for Menopausal Individuals With Elevated Dementia Risk
This trial is developing and pilot-testing a brief behavioral program called PERI-MIND for perimenopausal women who have a family history of Alzheimer's or dementia. The goal is to help them manage fear and anxiety about developing dementia themselves. This is a Phase NA development and feasibility study — meaning researchers are still building and refining the tool, not yet testing whether it prevents or treats any disease.
You may qualify if
- Female sex at birth
- Aged between 40-58 years
- Late perimenopause or early post-menopause
- Elevated dementia risk characterized by first degree relative with diagnosis of Alzheimer's disease or another dementia
You're excluded if
- Diagnosis of Mild Cognitive Impairment, Alzheimer's or another dementia
- Diagnosis of other chronic illness or condition that affects cognition (e.g., Axis I psychiatric disorders such as schizophrenia or mood disorders, neurological disorders such as stroke, cancer, traumatic brain injury)
- Inadequate vision or hearing to engage with intervention materials
- Unable or unwilling to provide informed consent
- Iatrogenic menopause (i.e., due to surgery)
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-02-05