NCT06880406 · RECRUITING
Mitochondrial Function and Metabolomic Profile in Alzheimer's Disease and Related Dementias
This study is testing whether mitochondria (the energy-producing parts of cells) behave differently in people with Alzheimer's versus other forms of dementia, using a simple cognitive test and a blood draw. Researchers also want to find metabolic markers in blood that may signal those mitochondrial changes. This is a Phase NA observational study — it is collecting data, not testing a treatment.
Eligibility criteria
Inclusion Criteria: * Neurocognitive disorder with spontaneous complaint or reported for at least 6 months * Diagnostic process according to current Haute Autorité de Santé (HAS) recommendations. * cerebrospinal fluid biomarker dosage done within the study center and agreement to bio-collection of residual cerebrospinal fluid * Patient having agreed to sign the informed consent * Patient affiliated or beneficiary of a social security scheme For alzheimer group : diagnosis of Alzheimer's disease according to NIA-AA 2024 criteria (presence of a pathogenic amyloid process in the cerebrospinal fluid) For non alzheimer group : diagnosis of mild or major neurocognitive disorder according to Manuel diagnostique et statistique des troubles mentaux edition 5 (DSM-V) criteria, not linked to Alzheimer's disease (absence of pathogenic amyloid process in the cerebrospinal fluid) Exclusion Criteria: - Vulnerable people
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-07-03