NCT06871488 · Phase 4 · RECRUITING
Predictors of Improvements in Irritability and Aggression in Children With ADHD Treated With CNS Stimulants
This trial is testing whether brainwave patterns measured by EEG can predict which children with ADHD respond well to stimulant medications for irritability and aggression. Researchers will optimize each child's stimulant dose, then run a short crossover comparing that dose to placebo while recording brain activity. It is a Phase 4 trial, meaning the medications are already approved — this study is asking who benefits most and why.
You may qualify if
- Meet criteria for any presentation of ADHD
- Moderate or worse impairment related to ADHD
- Elevated levels of irritability and/or aggression on guardian ratings of Affective
- Reactivity Index and Retrospective Modified Overt Aggression Scale
- fluent in English for child and guardian
- Guardian and child are willing to have child take CNS stimulant medication for ADHD
You're excluded if
- Medical contraindications to use of CNS stimulants
- Autism Spectrum Disorder,
- Bipolar Disorder,
- Intellectual/Developmental Delay
- current use of antipsychotic, mood stabilizing
- Use of other medications that impact EEG data collection (e.g. benzodiazepenes)
- hearing or visual deficits that impede ability to do computer tasks
- Current Major Depressive Episode
- Current suicidal ideation
- child has failed two fully optimized trials of methylphenidate products AND amphetamine products
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-03-16