NCT06833645 · RECRUITING
[18F]AV45(Aβ) and [18F]AV1451(Tau)PET/CT in the Diagnosis of Early Pathological Changes of Alzheimer's Disease
This study uses two specialized PET/CT brain scans to look for early signs of Alzheimer's disease. One scan detects amyloid plaques, the other detects tau tangles — the two hallmark proteins of the disease. Researchers want to map where these proteins appear first in the brain and link those patterns to standard cognitive test scores. The phase is unspecified, so this appears to be a diagnostic imaging research study rather than a drug or treatment trial.
Eligibility criteria
Inclusion Criteria: * Meet the MCI diagnostic criteria of Peterson in 2004; * The clinicaldementiarating Scale (CDR) score was 0.5; * Prominent memory loss may also be accompanied by impairment of other cognitive domains; * Insidious onset and slow progression; * Not at the level of dementia. AD entry criteria: * Meet the criteria for diagnosing dementia as described in the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-R), Use the diagnostic criteria for AD from the National Institute of Neurology, Speech and Communication Disorders and Stroke - Alzheimer's Disease and Related Disorders (NINCDS-ADRDA) or the National Institute on Aging and Alzheimer's Disease Association (NIA-AA). * Clinical Dementia Rating Scale score was 1 point. Exclusion Criteria: * Patients with a history of stroke and focal neurological signs, and imaging findings consistent with small cerebral vascular disease (Fazekas score ≥2); * The presence of other neurological disorders that can cause brain dysfunction (e.g., depression, brain tumors, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, brain trauma, Normal facial pressure hydrocephalus); * The presence of other systemic diseases that can cause cognitive impairment (such as liver insufficiency, renal insufficiency, thyroid dysfunction, severe anemia, folic acid or vitamin B12 deficiency, syphilis, HIV infection, alcohol and drug abuse, etc.); * There is mental and neurological retardation. * There are other diseases that are known to cause cognitive impairment.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-02-19