NCT06767124 · NOT YET RECRUITING
Supplementing Neuro-Energy to Aid Cognition
This trial is testing whether a ketogenic (high-fat, low-carb) dietary supplement can support brain energy in people with Alzheimer's disease and related dementias, compared to a placebo drink. Researchers are also developing new PET-MRI brain imaging tools to measure how the brain uses energy. This is a Phase NA study, meaning it is exploratory research focused on methods and measurement rather than proving a treatment works.
Eligibility criteria
Inclusion Criteria - Healthy Participants: Males and females, Age 21 - 80 years, BMI of 18.5-30 Inclusion Criteria - Alzheimer's Disease Participants: Positive amyloid and tau biomarkers (as noted by PET imaging, cerebrospinal fluid or blood), Mild cognitive impairment or mild-to-moderate dementia, BMI of 18.5-30 Exclusion Criteria: Contraindications to MRI (claustrophobia, metal implants, pacemakers, etc.), Pregnant or breastfeeding women, Neurological disease (healthy participants only), Mental illness, Overt cardio- or neurovascular disease, Recent participation in any procedure(s) involving radioactive agents
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-10-14