NCT06741865 · RECRUITING
The INSPIRE -Faith Study: Intervention Strategies for Preserving Intellectual Resilience and Engagement
The INSPIRE-Faith Study is testing whether a structured lifestyle intervention, compared to standard health education, can support cognitive health and reduce dementia risk in community members aged 55 and older. It is a Phase NA behavioral trial, meaning this is a practical intervention study rather than a drug trial testing safety and dosing. It involves 2,000 participants and is run through faith-based community partnerships in the Crenshaw, California area, with online participation also available.
You may qualify if
- Age: Participants must be 55 years of age or older.
- Ethnicity: Focused on African American individuals, but not exclusive.
- Cognitive Status: Participants must have normal cognitive status, mild cognitive impairment (MCI), or subjective cognitive impairment (SCI).
- Language: Participants must be fluent in English.
- Location: Must reside in the Crenshaw, California area or* be able to attend study-related activities in this location. *online access is available for those not in this area.
- Willingness to Participate: Participants must be willing to adhere to the study protocol, including attending assessments, participating in interventions, and completing questionnaires.
You're excluded if
- Cognitive Decline: Diagnosis of dementia or severe cognitive impairment that would interfere with the ability to participate in the study.
- Physical Limitations: Any physical or medical condition that would preclude participation in the lifestyle interventions (e.g., severe mobility issues).
- Recent Cancer Diagnosis: Diagnosis of cancer within the last three years, excluding stable cases of basal cell or squamous cell carcinoma of the skin, or stable prostate cancer.
- Pregnancy: Current pregnancy or planning to become pregnant during the study period.
- Mental Health: Diagnosis of severe psychiatric disorders such as schizophrenia or bipolar disorder that might interfere with participation.
- Substance Abuse: Current substance abuse or dependency that could impact participation.
- Hearing Impairment: Uncorrected hearing loss that would limit the ability to communicate and participate in the study.
- Non-English Speaking: Inability to participate in English-language oral and written cognitive assessments.
- Participation in Another Study: Currently enrolled in another clinical trial that could interfere with the INSPIRE Study.
- Life expectancy less than 3 years
- Unwillingness to share medical and laboratory information.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-05-28