NCT06739967 · RECRUITING
Speech and Language Interventions for Italian People With PPA
This pilot study is testing tailored speech and language therapy for people in Italy who have primary progressive aphasia, a condition that gradually erodes the ability to speak and understand language. Researchers want to see which therapy approaches help most across PPA's three variants, how long any gains last, and what brain and cognitive features predict who responds best. The phase is unspecified, meaning this is early exploratory work, not a proven treatment.
You may qualify if
- Diagnosis of PPA according to the current clinical criteria (Gorno-Tempini et al., 2011)
- Mild PPA defined using the Progressive Aphasia Severity Scale (PASS)
- Age between 40 and 85 years
- Patients with Italian mother tongue
- Patients with the ability to sign the informed consent
- Patients with the ability to comply with the study procedures
- Patients with stable pharmacological treatment for at least 4 weeks.
You're excluded if
- Mini-Mental State Exam (MMSE) Score \<15
- Presence of other neurological or psychiatric diseases, including cerebrovascular disease
- Severe and uncorrected hearing loss or visual disturbances
- Inability to repeat multi-syllable words (4 syllables)
- Concurrent participation in other pharmacological and non-pharmacological experimental studies
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-02-20