NCT06732128 · RECRUITING
Nature-based Virtual Reality Intervention for Depression in Alzheimer's Disease
This trial is testing whether nature-based virtual reality sessions delivered at home can reduce depression in people with mild to early-moderate Alzheimer's disease. Participants do two 15-minute VR sessions per week for four weeks. The comparison group watches nature videos instead. This is a feasibility trial — Phase NA means researchers are checking whether the approach is practical and safe before testing it at larger scale.
You may qualify if
- Clinical diagnosis of mild to early-moderate stage AD (including mixed dementia with AD) using the Diagnostic and Statistical Manual of Mental Disorders, 5th Ed. Criteria
- Age of 50 years or older
- Medical stability to participate in the trial
- Patient Health Questionnaire score 5-14
- Investigator judgement on whether the participant is comfortable with technology
- Access to WiFi and a smart device for connecting on WebEx and downloading the Fitbit and Muse applications
- Have someone available to be present during all sessions
You're excluded if
- Unstable medical or psychiatric condition, including substance use based on an investigator opinion
- Visual or hearing impairments that would impair participation
- Patient Health Questionnaire score 15-27 and/or score of 1 or 2 in section E question 1 of the Cornell Scale for Depression in Dementia
- Any other reason, which will make the study participation intolerable for the participant in the opinion of the study investigator
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2024-12-13