NCT06706947 · NOT YET RECRUITING
Exploration of the Efficacy and Mechanisms of Lymphaticovenous Anastomosis in the Treatment of Alzheimer's Disease
This trial is testing a surgical procedure called lymphaticovenous anastomosis — which connects lymphatic vessels to veins — to see whether it can improve cognition, daily functioning, mood, and sleep in people already diagnosed with Alzheimer's dementia. Researchers will also track brain imaging and blood biomarkers to understand how the procedure might work. This is a Phase NA exploratory study, meaning it is early-stage investigational work, not a proven or approved approach.
You may qualify if
- At least two deputy chief physicians or above, diagnosed with Alzheimer's dementia according to the DSM-5 diagnostic criteria;
- Age between 18-80 years old;
- The course of the disease is at least 1 year;
- MMSE score ≤ 24 points; MoCA score \< 26
- Brain MRI shows hippocampal atrophy;
- Patients and their families agree to participate in this project for surgical treatment and sign an informed consent form.
You're excluded if
- Individuals with contraindications for Lymphaticovenous Anastomosis; those allergic to anesthetics and contrast agents (indocyanine green);
- Those unable to cooperate with cranial magnetic resonance imaging and scale testing;
- Patients simultaneously suffering from schizophrenia, depression, bipolar disorder;
- Patients with severe somatic diseases (such as cardiovascular, liver, kidney, gastrointestinal, etc.), infectious diseases, and immune system disorders;
- Individuals with serious neurological diseases (such as epilepsy, cerebrovascular diseases, etc.), other types of dementia, mental retardation;
- Pregnant or lactating women.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2024-11-27