NCT06641726 · RECRUITING
Creating a Global Research Database That Connects Genetic Information and Long-term Health Data to Improve Personalized Treatment for People With Serious Mental Illness
This is an observational study — no drug or treatment involved. Researchers are building a large database of 50,000 people with serious mental illness or dementia, linking their genetic data, biomarkers, and health records over time. The goal is to better understand how these conditions cluster and what risk factors shape outcomes. Observational means they are watching and recording, not testing a treatment.
Eligibility criteria
Inclusion Criteria: - All participants must have an electronic health record in a primary or secondary care service. Mental Health cohort(s) • Have received a diagnosis and/or treatment/referral for mental illness for MDD, BD, Schizophrenia. • Having an available electronic health record • Current age 18+ (no upper age limit) • Can speak English Dementia cohort • Participants aged 18+ (no upper age limit) • Currently alive and are, or have been, old age psychiatry patients • Received relevant diagnosis or referral: EITHER • Clinical diagnosis of dementia, mild cognitive impairment (MCI) or subjective cognitive impairment (SCI) OR • Memory clinic referral • Must be willing and able to complete a validated cognitive assessment (MoCA or SLUMS). All dementia patients will undergo the extended biomarker analysis. Exclusion Criteria: - Mental Health cohort(s) • Patients without capacity to provide consent. Dementia cohort • Inability to understand spoken and/or written spoken English • Individuals with intellectual disability. • Patients with dementia in Creutzfeldt-Jakob disease (CJD), Huntington's, HIV dementia, alcohol-related dementia, intellectual disability, traumatic brain injury at any time. • Patients diagnosed with depression (only an exclusion criterion for MCI/SCI patients), psychosis, bipolar disorder prior in the pre-index period - to be checked at screening.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-10-03