NCT06534723 · Phase 3 · RECRUITING
Phase 3 Clinical Trial of Wujia Yizhi Granules in the Treatment of Mild-to-moderate Alzheimer's Dementia (Syndrome of Deficiency of Spleen and Kidney)
This trial is testing Wujia Yizhi granules, a traditional Chinese herbal medicine, against a placebo in people who already have mild-to-moderate Alzheimer's dementia. Researchers are measuring whether the granules are safe and whether they slow or reduce cognitive symptoms. Phase 3 means the drug has already shown early promise and is now being tested at a larger scale before any approval decision.
You may qualify if
- Male or female, age range : 50 - 80 years old.
- Informed consent signed and dated by patient or legal representative.
- The participants are mild-to-moderate AD patients who meet the diagnostic criteria for AD proposed by the National Institute on Aging and the Alzheimer's Association (NIA-AA) in 2018 and have a disease course of more than 6 months. If participants lack previous pathological evidence or biomarkers of Alzheimer's dementia, they must have evidence of β-amyloid deposition biomarkers during screening (PET with abnormal amyloid deposition or low cerebrospinal fluid Aβ 42 and Aβ 42/Aβ 40 ratio).
- MMSE score 11 to 26;CDR-GS score 1 to 2 。
You're excluded if
- Participants with non AD induced memory and cognitive impairment, such as diagnosis of other types of dementia, including but not limited to mixed dementia (AD VaD), vascular dementia (VD), Parkinson's disease dementia (PDD), Lewy body dementia (DLB), Huntington's disease related dementia, frontotemporal lobe dementia (FTD), etc; Endocrine system disorders (such as thyroid diseases, parathyroid diseases) and dementia caused by folate, vitamin B12 deficiency, or any other reason; Existence of consciousness disorders, etc.
- Participants have a history of epileptic seizures.
- Participants are psychiatric patients, including but not limited to schizophrenia, affective schizophrenic disorder, bipolar disorder, or delirium.
- HAMD-17 score ≥ 17 points.
- HAMA score ≥ 14 points.
- Participants were taking antidepressants, anxieties, and antipsychotic drugs during screening.
- HIS score ≥ 4 points..
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-12-29