NCT06528964 · RECRUITING
Proteinopathies Expression in Skin of Neurodegenerative Disorders
This observational study collects small skin biopsies from people who have been diagnosed with Alzheimer's disease, Parkinson's disease, or several related conditions, as well as from healthy volunteers. Researchers will look for abnormal protein clumps — including amyloid-beta and tau — in the skin samples and compare patterns across diagnoses. No phase is assigned because this is not a drug trial; it is a diagnostic research study.
Eligibility criteria
Inclusion Criteria for patients: * Patients 45 years and older * Men and women * Patients diagnosed with Alzheimer's disease, frontotemporal lobe dementia, Parkinson's disease, atypical Parkinsonism, amyotrophic lateral sclerosis or normal pressure hydrocephalus * Patients that voluntarily accept to participate in the study and accept the consent form Inclusion Criteria healthy control subjects: * People 45 years and older * Men and women * Subjects can be related to a patient but not by blood (for example spouse of a patient) * Subjects don't have direct family history of a neurodegenerative control * Subjects don't have any clinical findings suggesting dementia * Subjects voluntarily accept to participate in the study and accept the consent form Exclusion Criteria: * Patients or controls that have a personal history of cerebrovascular disease, psychiatric disease, post traumatic dementia or HIV related dementia * Patients in which the diagnosis is not clear or hasn't been confirmed * Patients or controls that have a neuroinfection * Patients or controls that a diagnosed skin disease * Patients that have an "atypical" presentation of the disease * Patients or controls that have diagnosis of a coagulopathy
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2024-12-16