NCT06452147 · RECRUITING
Anesthesia and Perioperative Neurocognitive Disorders in the Elderly Patients Undergoing Hip Fracture Surgery Platform Trial (ANDES Platform Trial)
This trial is testing whether different anesthesia techniques — nerve blocks, IV lidocaine, or a longer-acting local anesthetic — protect elderly hip fracture patients from cognitive problems after surgery, compared to standard anesthesia care. It is a Phase NA (pragmatic real-world) platform trial, meaning it is running multiple comparisons at once across many sites to find what works best in practice, not a small early-stage experiment.
You may qualify if
- Aged 65 years and older.
- Patients with unilateral hip fracture (including femoral neck, femoral head, intertrochanteric and subtrochanteric fractures) are scheduled for surgical treatment.
- American Society of Anesthesiologists (ASA) physical status IV or below.
- The patients or family members provide written informed consent.
- Additional inclusion criteria may pertain to specific interventions and will be described in relevant sub-protocols.
You're excluded if
- Patients with multiple trauma or fractures (excluding trauma that the researcher judges will not affect the patient's overall recovery, such as simple spinal compression fractures, mild soft tissue contusions, fractures of hands and feet, etc.);
- Two or more anesthetic surgeries are required.
- Petients with an obvious history of head trauma (such as loss of consciousness for more than 5 minutes, post-traumatic amnesia, etc.);
- Patients who the researcher believes are unable to complete the assessment of primary outcome;
- Additional exclusion criteria may pertain to specific interventions and will be described in relevant sub-protocols.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2024-11-08