NCT06448975 · RECRUITING
An Exploratory Study of Deep Cervical Lymphovenous Bypass (LVB) in Alzheimer's Disease
This trial is testing a surgical procedure called deep cervical lymphovenous bypass in people who already have Alzheimer's disease. The idea is that the brain clears harmful proteins like amyloid-beta and tau through a drainage system involving lymphatic vessels in the neck — and that improving that drainage surgically might help slow or reduce cognitive decline. This is a Phase NA exploratory study, meaning it is early and investigational, not yet proven or approved.
You may qualify if
- The age ranged from 60 to 80 years, and the time from initial diagnosis to enrollment was more than 12 months
- The estimated survival time is more than 12 months;
- The clinically diagnosed patients with mild to severe Alzheimer's Disease;
- The imaging examination has the correlation diagnosis evidence;
- Volunteer to participate in the project and sign an informed consent form with the guardian.
You're excluded if
- Complicated with other severe systemic underlying diseases;
- Unable to tolerate general anesthesia;
- The pregnant women;
- Recent severe infection or infectious diseases within 4 weeks;
- Unable to complete the evaluator or refused to complete the one-year clinical follow-up.
- Refusal to participate
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2024-07-12