NCT06402266 · COMPLETED
Simultaneous tDCS and Computerised Gamified Short-term Memory Task Feasibility
This small feasibility study is testing whether a non-invasive brain stimulation device called tDCS, worn as a headset, can be used comfortably by healthy APOE4 carriers while they play a computerised memory game on an app. Researchers want to know if stimulating one side of the brain works better than the other, or better than fake stimulation, for short-term memory performance. This is an early feasibility study, not a treatment trial.
You may qualify if
- Age range: 55-75 years old
- The participant is confirmed to carry at least one APOE ε4 allele on a blood test
- The participant has at least 7 years of education or a good working history
- Normal cognition (MMSE score > 26)
You're excluded if
- Any dementia
- Significant systematic disease
- Severe and unstable medical disease or psychiatric disorder, including medications for these diseases or disorders
- Past history of stroke or brain damage
- Epilepsy or history of epileptic seizures
- Migraine
- Skin or scalp condition in the areas where the electrodes will be placed
- Depression
- Alcohol or drug abuse
- Significantly impaired vision or hearing
- Colour blindness
- Adverse effects to previous tDCS or other brain stimulation techniques
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2024-05-07