NCT06340659 · RECRUITING
Concurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer's in At-risk Older Adults (The Exergames Telerehabilitation Study)
This trial compares two home-based, telehealth exercise programs for older adults who notice they are forgetting things more than before. One group does standard aerobic exercise via video; the other plays cognitive video games that also require physical movement, called exergames. Researchers are measuring thinking skills, fitness, and brain-related proteins in the blood. This is a Phase NA feasibility and preliminary efficacy trial, meaning they are testing whether the approach works well enough to study further.
You may qualify if
- Cognitive complaint (defined as answering yes to the questions's "Do you perceive memory or cognitve difficulties?" and "In the last two years, has your cognition or memory declined?";
- Montreal Cognitive Assessement (MoCA) 26 or greater
- Age 65 years and older;
- English-speaking;
- Without ACSM contraindication to exercise
You're excluded if
- Dementia or mild cognitive impairment diagnosis;
- Neurological or major psychiatric disorder, alcohol/chemical dependency or recent medical condition (anethesia COVID-19 ["brain fog"]) likely causing cognitive impairment;
- Current enrollment in another intervention study
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-08-12