NCT06321588 · RECRUITING
Autoimmune Dementia: Predictors of Neuronal Synaptic Antibodies in Patients With New-ONset Cognitive Impairment
This observational study is looking at whether certain antibodies produced by the immune system might attack brain connections and contribute to cognitive decline. Researchers want to know how often these antibodies show up in people with new cognitive impairment, and whether they might explain some cases that do not fit a typical Alzheimer's diagnosis. This is an observational study, meaning no treatment is being tested.
Eligibility criteria
Inclusion Criteria: * both sexes * adult (aged between 40 and 90 years) * patients with a diagnosis of new-onset neurocognitive disorders (major and minor), as defined by the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria, with onset within the previous 24 months Exclusion Criteria: - presence of a history of seizures within 4 weeks from onset.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-02-11