NCT06286293 · NOT YET RECRUITING
YOD-RiSoCo: Social Cognition and Risk-taking Behaviour in Patients with Young-onset Dementia
This observational study is examining how young-onset dementia affects social judgment and risk-taking. Researchers are comparing people who developed dementia before age 65 against patients with frontal brain injury and healthy controls, using neuropsychological tests and a driving simulator. No drug or treatment is being tested. Because no phase is listed, this is a research study gathering data, not a clinical treatment trial.
Eligibility criteria
Inclusion Criteria: All subjects * Sufficient command of the Dutch language * In possession of a driver's license with any driving experience throughout life * Age 18 to 65 bvYOD subjects * Probable diagnosis of young-onset dementia (before 65 years old), confirmed after interdisciplinary consensus meeting in which interviews, neuropsychological examination, neurological and psychiatric assessments, neuro-imaging, blood samples, and in some cases FDG/PIB-PETscans, CSF biomarkers or genetic counseling were discussed. * Nosological diagnosis of bvFTD or bvAD Non-bvYOD subjects * Probable diagnosis of young-onset dementia (before 65 years old), confirmed after interdisciplinary consensus meeting in which interviews, neuropsychological examination, neurological and psychiatric assessments, neuro-imaging, blood samples, and in some cases FDG/PIB-PETscans, CSF biomarkers or genetic counseling were discussed. * YOD subtypes other dan bvFTD or bvAD, such as amnestic variant AD. Frontal brain injury subjects - Neurological patients with frontal brain injury (e.g. traumatic brain injury, stroke or brain tumor patients). Exclusion Criteria: All subjects * Suffering from severe motion sickness; motion sickness is a risk factor for simulator sickness YOD subjects: - Presence of premorbid severe neurological or psychiatric pathology, non-related to dementia. Frontal brain injury subjects: - Presence of serious psychiatric disorders or other neurological comorbidities. Healthy control subjects: * Presence of serious psychiatric disorders * History of neurological disorders, which may interfere with cognitive functioning (e.g. recent concussion, previous subarachnoid or intracerebral haemorrhage, intracranial tumours, epilepsy, ischemic stroke).
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-01-10