NCT06263920 · RECRUITING
Neurofrailty: A Study of Late-onset Epilepsy and Its Associations
This observational study is following adults who developed their first seizure in adulthood — called late-onset epilepsy — to track their brain health over time. Researchers want to understand whether these seizures are connected to later conditions like stroke or dementia. There is no treatment being tested. This is an observational study, meaning researchers are watching and recording, not intervening.
Eligibility criteria
Inclusion criteria for case participants includes: * diagnosis of LOE or first seizure after the age of 18. * diagnosis confirmed or established at a tertiary neurology centre. * sequential cases will be used; in the unlikely event that eligible cases outstrip capacity, an annual cap of the first 150 patients per year per cohort will be used. Inclusion criteria for control participants includes: * established diagnosis of migraine. * with or without therapeutic medications with antiepileptic properties. Exclusion Criteria Exclusion criteria for case participants includes: * a 'lesional' attributable cause for seizures including malignancy, stroke (excluding transient ischaemic attack), hypoxic brain injury, trauma, vascular or congenital abnormality of likely aetiological significance. * people with migraine or headache syndrome can be included in case group - the presence or absence of a seizure syndrome is mutually exclusive between case and control groups, not the presence or absence of migraine. Exclusion criteria for control participants includes: * diagnosis of epilepsy or confirmed seizure. * 'lesional' attributable cause for seizures including malignancy, stroke (excluding transient ischaemic attack), hypoxic brain injury, trauma.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-04-08