NCT06164262 · RECRUITING
Dementia Risk Registry for Young and Middle-aged CSVD Patients in the Next 10 Years
This study is tracking people aged 30 to 60 who already show signs of cerebral small vessel disease on brain scans but do not yet have dementia. Researchers are building a registry and following participants over ten years to see who develops cognitive problems and why. It is an observational study, meaning no drug or treatment is being given — just monitoring and data collection.
Eligibility criteria
Inclusion Criteria: 1. Patients with any of the CSVD-related MRI imaging markers, including recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and superficial cortical siderosis. 2. Patients aged from 30 to 60 years. 3. Sign informed consent. Exclusion Criteria: 1. Unable to cooperate with inspectors. 2. Known dementia. 3. Other cognitive diseases (such as Alzheimer's disease, Parkinson's disease, or thyroid disease). 4. Serious systemic illness, such as heart, liver, kidney disease or major mental illness. 5. Contraindications for imaging examination. Exit Criteria: 1. Not meet the inclusion criteria. 2. For any poor adherence, not comply with the requirements of the follow-up, or safety reasons determined by investigator. 3. Any adverse or serious adverse events during the study period judged by investigator.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-05-21