NCT05984446 · COMPLETED
Targeting Default Mode Network Dysfunction in Persons At Risk of Alzheimer's Disease with Non-invasive Techniques
This trial is testing repetitive transcranial magnetic stimulation, or rTMS, a non-invasive brain stimulation technique, to see whether it can improve the function of the default mode network — a brain circuit known to break down early in Alzheimer's disease. Participants get either real rTMS or a sham version. Researchers will measure brain and cognitive changes using neuroimaging. This is a Phase NA (exploratory) study — early-stage, not yet proven or approved.
Eligibility criteria
Inclusion Criteria: * Age: 60 years and older * MMSE score > 24 Exclusion Criteria: * Pathological scores in at least two standardized cognitive tests * Participation in other interventional studies * Known carriers of an autosomal dominant genetic mutation associated to AD * Neurological, psychiatric or medical conditions not compatible with the study Exclusion Criteria for MRI and rTMS: * metal implants, pace-makers, prosthetic heart valves * claustrophobia * history of epilepsy * pregnancy
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-01-16