NCT05929924 · ACTIVE NOT RECRUITING
Does EVOO Induce Gene and Metabolic Changes in Healthy Subjects
This trial is testing whether adding extra virgin olive oil (EVOO) to your daily diet changes gene expression, lipid profiles, and metabolic markers in healthy adults who have a family history of Alzheimer's. Participants get about two tablespoons of EVOO a day for six months, and researchers will take blood samples before and after to look for biological changes. This is a Phase NA study — it is exploratory research, not a test of a proven treatment.
You may qualify if
- Cognitively normal and healthy individuals
- Have a family history of Alzheimer's disease.
You're excluded if
- Smokers
- Neuropsychiatric illness including depression, anxiety, seizures, attention deficit disorders, and cognitive deficit disorders.
- Pregnant or become pregnant during the study.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-04-20