NCT05922137 · RECRUITING
Oriental Intervention for Enhanced Neurocognitive Health (ORIENT) Diet in Patients With Intracranial / Carotid Stenosis
This trial is testing whether a specific diet — called the ORIENT diet, which appears to be an Asian-style eating pattern — can slow cognitive decline in people who have significant narrowing of arteries leading to the brain. Researchers are comparing it against standard dietary advice over six months, tracking thinking and memory tests, brain MRI scans, and blood and stool biomarkers. It is a Phase N/A trial, meaning it is a straightforward behavioral study rather than a drug safety or efficacy phase.
Eligibility criteria
Inclusion Criteria: * Patients aged ≥ 40 years * ≥ 50% stenosis in unilateral intracranial / carotid artery * Written informed consent available * Willingness to complete all assessments and participate in follow-up * Adequate Visual and auditory acuity to undergo neuropsychological testing Exclusion Criteria: * Previous history of major head trauma and any intracranial surgery * Intracranial abnormalities, such as intracerebral hemorrhage, subarachnoid hemorrhage and other space occupying lesions * Extrapyramidal symptoms or mental illness which may affect neuropsychological measurement * Severe loss of vision, hearing, or communicative ability * Nuts, berries, olive oil, or fish allergies * Patients presenting a malignant disease with life expectancy \< 3 years * Participation in an ongoing investigational drug study Exit Criteria: * Not meet the inclusion criteria * For any poor adherence, not comply with the requirements of the follow-up, or safety reasons determined by investigator * Any adverse or serious adverse events during the study period judged by Investigator
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-06-15