NCT05847985 · RECRUITING
Language and Lewy Body Diseases: Sentence Comprehension Problems and Modifying Noninvasive Brain Stimulation Treatment
This trial is testing whether a mild electrical brain stimulation technique called tDCS can help people with Lewy body diseases, specifically Parkinson's disease or dementia with Lewy bodies, who have language and comprehension difficulties. Researchers will first map how language breaks down in these patients, then see if home-based brain stimulation can help. This is a Phase NA, or non-standard phase, exploratory study, meaning it is early-stage and aimed at understanding the problem and testing feasibility, not proving a treatment works.
You may qualify if
- right-handedness
- Czech as their first language
- age (60-80 years)
- presence of PD-MCI (Litvan et al. 2012) or MCI-LB (McKeith et al. 2020) for LBD subjects
You're excluded if
- cardio pacemaker
- any MRI-incompatible metal in the body
- epilepsy
- any diagnosed psychiatric disorders
- alcohol/drug abuse
- for HC group the presence of LBDs or other neurodegenerative disorder or MCI/dementia
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-02-04