NCT05800028 · RECRUITING
Memory and Social Interactions
This study is testing whether social settings help people with Alzheimer's disease or semantic dementia learn and remember new information better. Researchers compare three social learning contexts — being near someone, watching someone, and working together — to see which conditions support memory most. It is not a drug trial. The phase is unspecified, suggesting this is observational or early-stage research rather than a treatment study.
Eligibility criteria
Inclusion criteria: * AD group: Age between 50 and 85 years, Diagnosis of probable Alzheimer's disease dementia with amnestic presentation and documented decline following the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. * SPPA group: Age between 50 and 85 years, Diagnosis of the semantic variant of primary progressive aphasia following the classification of primary progressive aphasia and its variants. * HC group: Age between 50 and 85 years, Matched in age and sociocultural status with one of the AD or SPPA patients, No cognitive complain, No recent reduction in social or cognitive activities, No contraindication to MRI examination. * Partners: Age over 18 years of age , No cognitive complaints, Social interactions of at least two hours per week for at least 5 years with one of the individuals of the other three groups. Exclusion criteria (for all groups): * Deprivation of liberty by judicial or administrative decision * Not being a member of a social security system * Concurrent participation in a therapeutic drug trial * Uncorrected visual and/or auditory disorders that are sufficiently significant to interfere with the protocol * History of neurological disorders (stroke, epilepsy, head trauma with loss of consciousness for more than one hour) * History of chronic alcoholism or drug abuse * History within the last 10 years of a clinically significant major psychiatric disorder * Cancer within the past 5 years, except for squamous cell carcinoma * Use of medications that may affect cognitive and/or brain function. Given the number of molecules involved and the dosages, the principal investigator will judge on a case-by-case basis whether regular use of certain medications will interfere with the study
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2024-09-20