NCT05741853 · RECRUITING
Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia
This trial is testing two speech-language therapy approaches — script training and word-finding practice — in bilingual people who have primary progressive aphasia, a brain disease that attacks language first. Researchers want to know whether tailoring therapy to both of a person's languages works better than standard approaches. This is a Phase NA efficacy trial, meaning it is evaluating how well the intervention works in a specific population, not yet a large-scale proven treatment.
You may qualify if
- Meets diagnostic criteria for Primary Progressive Aphasia (PPA; Gorno-Tempini et al., 2011)
- Bilingual in Spanish and Catalan or bilingual in Spanish and English
- Different proficiency levels across languages are expected, any prior experience in both languages is acceptable
- Intervention study: Score of 15 or higher on the Mini-Mental State Examination
- Note that this project will also recruit individuals to participate in assessment only, for these individuals the following inclusion criteria applies: Score of 10 or higher on the Mini-Mental State Examination
You're excluded if
- Other central nervous system or medical diagnosis that can cause symptoms
- Other psychiatric diagnosis that can cause symptoms
- Significant, uncorrected visual or hearing impairment that would interfere with participation
- Prominent initial non-speech-language impairments (cognitive, behavioral, motoric)
- Intervention Study: Score of less than 15 on the Mini-Mental State Examination
- Note that this project will also recruit individuals to participate in assessment only, for these individuals the following inclusion criteria applies: Score of less than 10 on the Mini-Mental State Examination
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-11-12