NCT05601856 · RECRUITING
Gut Microbiome and Blood Indices in Patients With AD and Their Spousal Caregivers
This study is not a treatment trial. Researchers are comparing gut bacteria and blood markers in three groups: people with Alzheimer's dementia, their spouses, and unrelated healthy adults. The goal is to see whether spousal caregivers show the same gut health abnormalities found in AD patients. There is no intervention — it is observational only. Details on phase are not provided, consistent with a non-interventional study.
You may qualify if
- patients with AD whose clinical dementia rating (CDR) is > 1
- Spouses of Patients in the above group Or
- Healthy adult unrelated to groups 1 and 2, with no history of dementia And
- Regardless of the grouping, the prospective subject must be between 65 and 90 years old
You're excluded if
- Familial Alzheimer's Disease (AD)
- Severe cardiovascular disease
- Severe respiratory system disease
- Severe liver disease
- Severe kidney disease
- Severe central nervous system diseases
- Having a lifespan of fewer than 3 months
- History of psychiatric illness
- Major neurological diseases other than AD
- Current use of corticosteroids, antibiotics, or bowel motility modification agents
- Any history of Alcoholism or illicit drug dependence
- Previous inclusion in this study
- Difficulty with follow-up or poor compliance
- Severe hearing impairment
- Severe vision impairment
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-03-27