NCT05599425 · RECRUITING
Health Behavior Change in Midlife Adults at Risk for Alzheimer's Disease
This trial tests two versions of a healthy-living education program aimed at helping middle-aged adults make lasting lifestyle changes — better diet, more physical activity, stress management, and mental engagement. Researchers want to know which approach works better for sustaining those changes over time. It is a Phase NA (non-drug, behavioral) study, meaning it is testing whether the program works, with no experimental medication involved.
You may qualify if
- age 45-69 years
- normal cognition (Minnesota Cognitive Acuity Scale > 52)
- English language fluency
- at least two of the following: i) BMI > 24.9; ii) systolic blood pressure > 125 mmHg; iii) LDL cholesterol > 115 mg/dL; iv) HbA1C > 6.0%; v) at least one APOE ε4 allele; vi) first-degree relative with AD.
You're excluded if
- history of serious mental illness (i.e., schizophrenia, bipolar disorder)
- history of neurologic or neurodevelopmental disorder
- current alcohol or drug use disorder based on self-report
- current enrollment in an AD prevention clinical trial.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2024-07-25