NCT05557617 · ACTIVE NOT RECRUITING
Periodontitis and Periodontal Bacteria in Dementia
This observational study is asking whether gum disease and specific mouth bacteria are linked to dementia and cognitive decline. Researchers in Sweden are analyzing stored spinal fluid samples from memory clinic patients to see whether a bacterium called Porphyromonas gingivalis shows up in ways that might connect it to Alzheimer's disease. There is no experimental treatment here — this is a data-gathering study, not a drug or intervention trial.
Eligibility criteria
Inclusion Criteria: - Any person that has been investigated for possible cognitive impairment at Minnesmottagningen, Department of Geriatric Medicine, Örebro University Hospital, and has a CSF sample stored in the biobank. This includes patients who received a diagnosis of dementia (major cognitive disorder) and patients not so diagnosed. Exclusion Criteria: * No CSF sample available in biobank * Incomplete or unavailable clinical and radiological data in medical and dental records, concerning e.g. cognitive tests and AD-biomarker analyses * Dementia with known etiological diagnosis, e.g. dementia due to alcohol use disorder or traumatic brain injury. * Creutzfeldt-Jakob disease or other transmissible prion disease * Non-consenting persons
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2024-04-10