NCT05443633 · RECRUITING
Enhancing Language Function in Aphasia
This trial is testing whether individualized speech-language training works better than standard language therapy for people with aphasia — a language impairment caused by stroke or a specific type of dementia called primary progressive aphasia. Researchers are also using brain imaging to understand how the brain responds to treatment. This is a Phase NA behavioral study, meaning it compares two therapy approaches rather than testing a drug.
You may qualify if
- Present with speech-language impairment (aphasia) caused by stroke or dementia
- A medical diagnosis of primary progressive aphasia (PPA) by a neurologist or physician
- Are native speakers of English
- Present with no contraindications for MRI
- Have adequate (normal or corrected to normal) vision and hearing
You're excluded if
- Individuals diagnosed with mood, anxiety, psychotic or substance abuse disorders.
- Individuals with highly magnetizable metallic implants, including certain dental work, may be excluded due to image quality in MRI.
- Individuals with other neurological disorders besides the ones of interest for the study (e.g., epilepsy, Multiple Sclerosis, Parkinson's Disease)
- Individuals with contraindications for MRI. This includes but is not limited to pacemakers, metallic cardiac pumps, valves, magnetic materials such as surgical clips, implanted electronic perfusion pumps, or any other condition that would preclude proximity to a strong magnetic field.
- Individuals suffering from clinically significant claustrophobia
- Severe systemic disease (e.g., renal failure)
- Poor overall health
- Individuals who are pregnant
- Individuals with a history of epileptic activity in the past 12 months
- Individuals with a personal or family history of epilepsy or other seizure disorders will not be included in the study.
- Individuals who have had a brain surgery in the past
- Individuals with implanted metallic skull plates or intracranial implants
- Individuals with skin lesions or skull damage
- Individuals who have a history of excessive use of alcohol or drugs
- Individuals with premorbid psychiatric disease affecting communication
- Individuals with severe non-linguistic cognitive disturbances impeding language therapy
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2024-12-09