NCT05368350 · ACTIVE NOT RECRUITING
Treating Primary Progressive Aphasia and Apraxia of Speech Using Non-invasive Brain Stimulation
This trial is testing whether a gentle electrical current applied to specific brain regions can improve speech and language problems in people with primary progressive aphasia or progressive apraxia of speech. Researchers will measure changes using speech and language assessments and brainwave recordings. This is a Phase N/A trial, meaning it is an interventional study outside the standard phase framework — typically exploratory or feasibility-focused rather than a large-scale efficacy test.
You may qualify if
- 18 to 85 years of age
- A formal diagnosis of primary progressive aphasia (nonfluent/agrammatic, semantic, logopenic variants or mixed) and/or progressive apraxia of speech
- Capable of understanding and signing an informed consent. Medical information/history, as well as mental status exam and diagnosis provided by referring physician will determine whether or not a caregiver is required to be involved during this process.
You're excluded if
- Has an implanted device, such as a pacemaker, metallic cranial implant, or a neurostimulator
- Skull defects
- Pregnant
- A significant history of arrhythmia or epileptic seizures.
- Not a native English speaker
- Currently receiving speech-language intervention
- Unable to communicated verbally
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-05-08