NCT05027789 · ACTIVE NOT RECRUITING
Brain Boosters 2 in Persons at Risk for Alzheimer's Disease: a Digital Application Supported Intervention
This trial is testing whether teaching older adults memory strategies and healthy habits (exercise, mental activity, stress management) improves day-to-day thinking and memory. One group follows a self-guided program; the other gets structured sessions plus a digital tracking app on an iPad. It runs six months with check-ins over a year. This is a Phase NA behavioral study, meaning it is evaluating a lifestyle program, not a drug.
Eligibility criteria
Inclusion Criteria: * The target population is cognitively normal older adults with Subjective Cognitive Concerns (SCC). SCC will be operationalized as 1. a positive complaint in response to the question: 'Have you experienced a decline in your memory or other aspect of thinking in the last 1-3 years that seems worse than others of your age' 2. normal cognition on the modified Telephone Interview of Cognitive Status (mTICS) 3. independent function in daily life. * Age 65 or older * English speaking * Lower level of engagement in healthy lifestyle behaviors and compensation use at study baseline (i.e., broadly defined as not a regular exerciser) * Approval from primary care (due to physical exercise component of the intervention) * Open to utilizing digital tools such as a digital calendar in daily life Exclusion Criteria: * Known diagnosis of dementia or cognitive impairment; * Other known neurological condition with potential to affect cognition (e.g., Parkinson's disease) * Reported history of severe psychiatric disorder (e.g., self-reported history of bipolar disorder or schizophrenia or other psychotic disorder) * Inability to complete the study protocols due to severe vision or hearing difficulties. * Has previously participated in a previous version of Brain Boosters, or another study utilizing the Digital Memory Notebook (DMN) application or EMMA.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-10-08