NCT04992195 · RECRUITING

Impact of COVID-19 Vaccines on Cerebrovascular Health

This observational study is tracking whether COVID-19 vaccines have any measurable effect on brain and vascular health over time. Participants get blood tests and cognitive screening before and after vaccination. There is no experimental drug — researchers are watching what happens naturally in a vaccinated population. The phase is unspecified, which fits an observational design: this is data-gathering, not a drug or device being tested for approval.

Eligibility criteria

Inclusion Criteria:
All consecutive citizens in the CUHK Brain Health Longitudinal Study cohort who received baseline MRI brain.
Exclusion Criteria:
1. Citizens with clinically evident stroke or dementia prior to recruitment; or
2. Citizens who are unable to provide an informed consent; or
3. Citizen with contraindications to MRI brain, e.g., non-MRI compatible implants, claustrophobia, etc; or
4. Citizens who had no baseline MRI brain assessment.

The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.

Eligibility criteria as of 2026-02-24

View full record on ClinicalTrials.gov

All APOE4 clinical trials