NCT04699786 · ACTIVE NOT RECRUITING
Returning Research Results That Indicate Risk of Alzheimer Disease Dementia to Healthy Participants in Longitudinal Studies
This trial is studying what happens when researchers share a personalized five-year risk estimate for Alzheimer's dementia with healthy older adults who have already had brain scans or blood tests and genetic testing through Washington University's Knight ADRC program. It is a Phase NA study, meaning it is not testing a drug or device but rather evaluating the psychological and practical impact of giving people this kind of sensitive risk information.
You may qualify if
- Current Knight ADRC participants who had their clinical assessment in the previous year.
- Minimum age of 65 years old
- Participant must be classified as cognitively normal (CDR® = 0) at their last clinical assessment.
- Participant has either recent research brain MRI and amyloid PET scan results, or recent plasma amyloid measurements (ideally within the past two years, but up to five years will be acceptable due to COVID-19-related delays).
- Participant has genetic research results available including APOE status.
- Participant is currently consented to be contacted for other research opportunities through the Knight ADRC.
You're excluded if
- There are no exclusion criteria, other than not meeting all of the inclusion criteria listed above.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-03-10