NCT04458207 · ACTIVE NOT RECRUITING
Cognitive Changes and Neural Correlates After Rehabilitation of Masticatory Function in Elderly -an Intervention Study
This trial is testing whether restoring chewing ability through dental implants or fixed dental work improves memory and learning in older adults who have significant tooth loss. Researchers will use cognitive tests and brain MRI scans to look for changes before and after the dental work. This is a Phase NA interventional study — meaning it is exploring a cause-and-effect question in humans for the first time, not testing a drug.
Eligibility criteria
Inclusion Criteria: * 65-80 years of age at start * Impaired chewing ability (Eichner index B2-B4, C1-C4) * Dental rehabilitation with fixed prosthodontics, implant and/or tooth supported (overdentures included) >10 occluding units * Mini Mental State Examination (MMSE) score >25 Exclusion Criteria: * Brain trauma or stroke \<6 months * Neurological disease (stroke, dementia, Alzheimer disease, Parkinson disease). * Intellectual disability * Psychological disorders * Participants with chronic pain, depression or sleeping disorders * Daily analgesic medication that may affect cognitive and/or executive performance of the brain * Poor Swedish language skills, reading disabilities * Severely reduced hearing or vision * Prosthetic treatment with removable dentures (full or partial) MRI exclusion criteria: * Claustrophobia * Difficulties in lying down in a supine position for about an hour, or any other difficulties related to the MRI head coil * Participants with metal or medical implants in the body contraindicating MRI scan
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-09-26