NCT04312399 · RECRUITING
Hormone Replacement Trial Against ALzheimers' Disease
This trial is studying whether hormone replacement therapy (HRT) around the time of menopause affects Alzheimer's-related proteins in the blood. Researchers will draw blood from postmenopausal women — with and without a history of breast cancer — and measure amyloid breakdown products to better understand the connection between menopause, hormones, and early Alzheimer's biology. This is a Phase NA observational-style study, meaning it is exploratory research, not a test of a treatment.
You may qualify if
- postmenopausal women
- 40 - 65 years
You're excluded if
- Longer than 10 years in menopause
- thyroid dysfunction
- hypertension
- medical history of psychiatric comorbidity
- Alcohol and/or drug abuse
- medical history of neurologic symptoms with cognitive symptoms
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-01-27