NCT04279743 · UNKNOWN
Fatty Acid Metabolism in Carriers of Apolipoprotein E Epsilon 4 Allele: Determining the Blood-to-brain Link
This trial is testing whether two different forms of omega-3 supplements — one packaged as phospholipids, one as triglycerides — deliver DHA (the brain-healthy fat in fish) to the brain differently, and whether APOE4 carriers absorb and transport DHA less efficiently than non-carriers. It is a mechanistic study, not a treatment trial — meaning researchers are trying to understand a biological process, not prove a therapy works.
Eligibility criteria
Inclusion Criteria: - Men and women aged between 30-50 years old. Exclusion Criteria: * Tobacco use, * Malnutrition (assessed from blood albumin, hemoglobin and lipids), * Diabetes, * Participants taking an EPA+DHA supplement or consuming more than 2 fish meals per week, * Uncontrolled thyroid, renal and endocrine disorder disease, * Chronic immune condition or inflammation (CRP > 10 mg/l, white cell count), * Cancer, * Recent major surgery or cardiac event, * Pregnant or lactating women, * Pre-menopause or menopause, * Dementia, * Ongoing or past severe drug or alcohol abuse, * Psychiatric difficulties or major depression * Ongoing or past intensive physical training.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2020-05-07